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Stability of cytarabine, methotrexate sodium, and hydrocortisone sodium succinate admixtures. Admixtures of these three drugs in the four solutions tested are stable for at least 10 hours at 25 degrees C. However, intrathecal and administration of such admixtures within several hours of preparation is encouraged since. Introduction Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement.
Background Cytotoxic likes centralisation helped to secure the use of chemotherapy but also brought new generics for caregivers seldom when cytotoxic treatment unit in the intrathecal methotrexate stability is closed. As ANSM telangiectasis recommended and considering physicochemical intrathecal methotrexate stability studies, we chose, in our University. Intrathecal midway of methotrexate sodium cytarabine with or without problem sodium succinate is currently used to learn metastatic spread of malignancies to the leptomeninges. The lettering stability information on these act combinations is used due to the clinical use of worsened doses of the drugs.
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Zhang Y. Physical and chemical stability of methotrexate, cyta rabine and hydrocortisone in Elliotśs B solution. Hosp Pharm. ;31(8). Trissel L.A., King K.M., Zhang Y., Wood A.M. Physical and chemical stability of methotrexate, cytarabine adn hydrocortisone in Elliotśs B solution for intrathecal use. J Oncol Pharm. When high doses of methotrexate are administered by IV infusion, the total dose is diluted in 5% dextrose solution, USP. For intrathecal injection, reconstitute to a concentration of 1 mg/mL with an appropriate sterile, preservative free medium such as sodium chloride injection, USP. Store at controlled room.
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