Category: Benadryl & Diphenhydramine
Psychopharmacology (Berl). Jun;(1) Higher occupancy of muscarinic receptors by olanzapine than risperidone in patients with schizophrenia. A[I]-IDEX SPECT study. Lavalaye J(1), Booij J, Linszen DH, Reneman L, van Royen EA. Author information: (1)Department of Psychiatry, Academic Medical. Risperidone contains the functional groups of benzisoxazole and piperidine as part of its molecular structure. Although not a butyrophenone, it was developed with the structures of benperidol and ketanserin as a basis. It has actions at several 5-HT (serotonin) receptor subtypes. These are 5-HT2C, linked to weight gain, Medical uses · Adverse effects · Pharmacology · Society and culture.
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Johnson et al. also found that low concentrations of olanzapine and clozapine (but not risperidone or ziprasidone) can markedly and selectively impair cholinergic-stimulated insulin secretion by blocking muscarinic M3 receptors in isolated rat islet cells. In vitro binding and functional data also showed that Abstract · Introduction · Conclusions · References. rinic receptor occupancy by olanzapine compared with risperidone in patients with schizophrenia stabilised on medication. Methods: Five patients with schizophrenia treated with olanzapine and five patients treated with ris- peridone were studied. Muscarinic receptor occupancy in the striatum and cortex was studied in vivo.
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